Robertsonian Chromosomes Exact Break
Robertsonian translocations occur when two acrocentric chromosomes fuse at their centromeres after precise breaks near the short-arm regions. These exact breaks typically happen at or close to the centromeric regions, leading to the loss of short arms (which usually carry redundant rRNA genes) and the joining of two long arms into a single metacentric or submetacentric chromosome. This structural rearrangement reduces the chromosome number by one but usually preserves genetic balance, though it can impact fertility and chromosomal segregation in carriers.
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